Design of Electrical Characterization Method for Electroporation-Treated Biological Tissues

The design of a method to evaluate the efficacy electroporation-treated (with several pulses) tissues is proposed. This based on application both standard and non-standard electrical characterization biological tissues, platform, containing samples under test, adopted have minimal invasive contact measurements. Standard direct current was performed for comparison. For electroporated (using eight pulses), behavior tissue in working condition, governed by high intensity short duration square wave stimuli, typically used electrochemotherapy treatments, utilized. Both electroporation stimuli testing were using same electrodes parallel plate configuration parallelepiped shaped samples. not removed during designed procedure reduce interaction with test effect different resistances. A finite element analysis-based numerical evaluation cell also performed, constant an electric field-dependent conductivity, showing its robustness. tested potato samples, as example biomaterial, whose conductivity field-dependent. subjected pulse voltage 100μs long, order multiple pulses, single protocol parameter. Results indicate dependency field strength applied easily scalable usable starting point evaluating other parameters.